CDKN2B and TSC1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDKN2B	TSC1
Description		cyclin dependent kinase inhibitor 2B	TSC complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases		Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus	Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Ankle-brachial index ( 22199011) Basal cell carcinoma ( 24403052 25855136 27539887) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 22144573 23561647) Coronary artery disease ( 21239051 29263402 26708285 29212778) Coronary heart disease ( 21971053 17554300 21378990 29615537) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Cutaneous malignant melanoma ( 32341527) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145 26545403) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 22293688 22961080 20581827 19401414 17463246 30718926 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		64 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2A CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17	99 interacting genes: AKT1 APPL2 AQP1 ARAF ARID5A ATXN1 AURKA BAG3 BECN1 C1orf94 CCDC120 CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CHCHD2 CSTF2 DMRT3 DOK5 ENKD1 EZR FAM110A FAM222B FGFR4 FOXH1 FRS3 GLIS2 GPANK1 HOXC8 HR HSH2D IGFN1 IKBKB KAT2A KDM1A LATS2 LENG1 LMO2 MAP2K5 MAPK14 MSN MYC MYLIP MYOZ3 NEFL NF2 PATL1 PATZ1 PITX1 PLK1 PLK2 POGZ POU6F2 PPP1R18 PPP1R32 PRMT6 RASSF1 RBPMS RDX RHEB RIN1 RIN3 SAMD11 SAMD7 SH2D2A SHC3 SMG9 SOX4 SPAG8 SUOX TBC1D7 TBX6 TCF7L2 TFAP2D TLE5 TNS2 TSC2 TSGA10IP TSHZ3 VENTX VEZF1 VGLL3 VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF587 ZNF765
Entrez ID		1030	7248
HPRD ID		02696	05594
Ensembl ID		ENSG00000147883	ENSG00000165699
Uniprot IDs		K7PPU3 P42772	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs			4Z6Y 5EJC
Enriched GO Terms of Interacting Partners?
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