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NPHP1 and ARHGAP32
Data Source:
BioGRID
(two hybrid)
NPHP1
ARHGAP32
Description
nephrocystin 1
Rho GTPase activating protein 32
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Cell-cell Junction
Adherens Junction
Bicellular Tight Junction
Cilium
Membrane
Motile Cilium
Photoreceptor Connecting Cilium
Golgi Membrane
Fibrillar Center
Nucleoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Cell Cortex
Endosome Membrane
Postsynaptic Density
Actin Cytoskeleton
Dendritic Spine
Molecular Function
Structural Molecule Activity
Protein Binding
GTPase Activator Activity
Protein Binding
Phosphatidylinositol Phosphate Binding
Biological Process
Signal Transduction
Excretion
Visual Behavior
Cell Projection Organization
Actin Cytoskeleton Organization
Spermatid Differentiation
Retina Development In Camera-type Eye
Protein Localization Involved In Establishment Of Planar Polarity
Ciliary Basal Body-plasma Membrane Docking
Cell-cell Adhesion
Positive Regulation Of Bicellular Tight Junction Assembly
Small GTPase Mediated Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Anchoring of the basal body to the plasma membrane
Rho GTPase cycle
Drugs
Diseases
Joubert syndrome
Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
Senior-Loken syndrome
GWAS
Intracranial aneurysm (
30823506
)
Iris color (L* coordinate) (
29109912
)
Macular thickness (
30535121
)
Metabolite levels (5-HIAA) (
23319000
)
Refractive error (
32231278
)
Interacting Genes
16 interacting genes:
ADAM15
ARHGAP32
BCAR1
FBXO7
FLNA
FLNB
FLNC
INVS
KHDRBS1
NPHP3
NPHP4
PAK2
PTK2B
TNK2
TUBB
UBQLN4
33 interacting genes:
ABI2
ATXN1
BCAR1
CAMK2N2
CDC42
CDH1
CDH2
CRK
CRKL
CTNNB1
DLG4
DZIP3
FYN
GAB1
GAB2
GRAP
GRB2
GRIN2A
GRIN2B
LHX2
MDFI
MEGF10
NCK1
NCK2
NPHP1
NTRK1
PIK3R1
PLCG1
RAC1
RHOA
SHC3
SRC
TLE5
Entrez ID
4867
9743
HPRD ID
09524
12257
Ensembl ID
ENSG00000144061
ENSG00000134909
Uniprot IDs
C9JNM7
O15259
A7KAX9
Q86T64
PDB IDs
1S1N
6O1Q
3IUG
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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