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DAZAP2 and UBA52
Data Source:
BioGRID
(two hybrid)
DAZAP2
UBA52
Description
DAZ associated protein 2
ubiquitin A-52 residue ribosomal protein fusion product 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Nuclear Speck
Protein-containing Complex
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Cytosolic Small Ribosomal Subunit
Endocytic Vesicle Membrane
Vesicle
Host Cell
Extracellular Exosome
Molecular Function
Protein Binding
Receptor Tyrosine Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
WW Domain Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Biological Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Activation Of MAPK Activity
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Translational Initiation
Cellular Protein Modification Process
SRP-dependent Cotranslational Protein Targeting To Membrane
Protein Targeting To Peroxisome
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Wnt Signaling Pathway
Endosomal Transport
Protein Ubiquitination
Protein Deubiquitination
Viral Life Cycle
Virion Assembly
Viral Transcription
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
Translesion Synthesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Nucleotide-excision Repair, DNA Incision
TRIF-dependent Toll-like Receptor Signaling Pathway
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Transmembrane Transport
Membrane Organization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Error-free Translesion Synthesis
Intracellular Transport Of Virus
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
Circadian Clock
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Maturation of protein E
Maturation of protein E
Negative regulation of FLT3
FLT3 signaling by CBL mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
164 interacting genes:
AATF
ACOT7
AOC1
ARID5A
ATXN1
ATXN1L
BAG3
BATF2
BHLHE40
C1orf94
CALCOCO2
CAMK2A
CAPN15
CCDC120
CDK4
CELF5
CEP70
CLASRP
COL4A2
COL4A5
CXCL12
DAB1
DAZ1
DAZL
DCUN1D1
DESI1
DTX2
EPN1
EPN2
EPN3
ESRP1
EXD3
FAM168A
FAM83A
FBN3
FOXH1
GGA3
GPS2
GPSM1
HEY1
HGS
HIP1
INCA1
KLHL42
KRTAP19-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP6-1
KRTAP6-2
KRTAP8-1
LASP1
LGALS9
LITAF
LMO2
MAGED1
MAPK1IP1L
MED31
MINDY1
MINDY3
MTURN
MYEOV
MYOZ3
NDUFA5
NEDD4
NEDD4L
NOC4L
NOTCH1
OPTN
OTUB2
OTUD7B
OTULIN
PATZ1
PDIK1L
PEF1
PITX2
PLEKHB2
PLEKHF2
PLSCR1
PLSCR4
POGZ
POLI
PROP1
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR34
RABGEF1
RAD18
RAD23A
RAMAC
RBFOX1
RBFOX2
RBM11
RBM24
RBM43
RBPMS
RHOXF2
RNF115
RNF208
RNF44
ROR2
RPS27A
SEPTIN2
SMAP2
SMURF2
SNRPC
SOX10
SOX6
SQSTM1
STAM2
STAT6
TAX1BP1
TBX6
TCF7L2
TENT5B
TENT5C
TEX37
TFG
TIAL1
TLE1
TLE5
TNIP1
TNIP3
TOLLIP
TOM1
UBA52
UBAC1
UBAP2
UBASH3A
UBASH3B
UBB
UBC
UBE2D4
UBE2E2
UBE2E3
UBE2V1
UBE3A
UBQLN1
UBQLN2
UBQLN4
UBXN6
UBXN7
USP13
USP5
VENTX
VEZF1
VHLL
VPS37C
WDR73
WWOX
WWP1
YOD1
ZBTB32
ZC3H10
ZFAND2A
ZFAND2B
ZFYVE9
ZNF34
ZNF581
39 interacting genes:
ACVR1
ARRDC3
BMPR1B
DAZAP2
DESI1
DNAJB2
EPN2
FAM168A
FSHR
GRB2
HERC3
HGS
KHDRBS1
LAPTM5
LITAF
MAPK6
MTURN
NCK1
PLEKHB2
PLSCR4
POLI
RABGEF1
RAD23A
RNF11
SLC2A4
SMAD1
SMAD2
SMAD4
SMURF1
SQSTM1
TAX1BP1
TGFBR1
TSG101
UBQLN1
UBQLN2
USP46
USP7
VPS28
WBP2
Entrez ID
9802
7311
HPRD ID
08463
08931
Ensembl ID
ENSG00000183283
ENSG00000221983
Uniprot IDs
A0A024R110
Q15038
P62987
Q3MIH3
Q7Z4P3
PDB IDs
2LJ5
2MBH
2MJB
2MUR
2N3U
2N3V
2N3W
2NBD
2NBE
2RSU
4HJK
4JIO
4P4H
4PIG
4PIH
4PIJ
4RF0
4RF1
4S1Z
4UG0
4V6X
4XKL
5AJ0
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5HPK
5HPL
5HPS
5HPT
5J26
5J8P
5JBV
5JBY
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
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