TSPAN2 and SLC30A8

Data Source:
BioGRID (two hybrid)

		TSPAN2	SLC30A8
Description		tetraspanin 2	solute carrier family 30 member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Plasma Membrane Integral Component Of Membrane Myelin Sheath	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Inflammatory Response Brain Development Astrocyte Development Microglia Development Myelination Oligodendrocyte Differentiation Axon Development	Zinc Ion Transport Cellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Secretion Positive Regulation Of Insulin Secretion Sequestering Of Zinc Ion Response To Interferon-gamma Glucose Homeostasis Regulation Of Vesicle-mediated Transport Regulation Of Sequestering Of Zinc Ion Response To Interleukin-1 Zinc Ion Transmembrane Transport
Pathways			Insulin processing Zinc efflux and compartmentalization by the SLC30 family
Drugs
Diseases			Type II diabetes mellitus
GWAS		Dysmenorrheic pain ( 27454463) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Migraine ( 27182965 23793025 27322543) Migraine without aura ( 23793025 27322543)	Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting plasma glucose ( 25187374 28270201) Glycated hemoglobin levels ( 24647736 19096518 28898252) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 27189021 22885922 24509480 17293876 30054458 22693455 26961502 29358691 30297969 19734900 29632382 26818947 31217584 23945395 31118516 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590 17460697 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)
Interacting Genes		35 interacting genes: ABHD16A ATP1B4 BSCL2 CD79A CLDN5 CLEC14A CREB3 CREB3L1 DCBLD2 FAM209A FKBP7 FOS GRB2 IFNGR2 KDELR3 LEPROTL1 LMNA MFF MGST3 PGRMC2 PIK3R3 RABGAP1L REEP4 RNF19B SCN3B SLC10A6 SLC30A8 SLC35C2 TMEM130 TMEM14B TMEM31 TMX2 TSPAN31 VSIR ZFYVE27	70 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27
Entrez ID		10100	169026
HPRD ID		18233	15370
Ensembl ID		ENSG00000134198	ENSG00000164756
Uniprot IDs		B1AKP1 B2RD31 O60636	Q8IWU4
PDB IDs			6XPD 6XPE 6XPF
Enriched GO Terms of Interacting Partners?
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