SLC30A8 and THSD7B

Data Source:
BioGRID (two hybrid)

		SLC30A8	THSD7B
Description		solute carrier family 30 member 8	thrombospondin type 1 domain containing 7B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Zinc Ion Transport Cellular Zinc Ion Homeostasis Response To Glucose Response To Zinc Ion Insulin Secretion Positive Regulation Of Insulin Secretion Sequestering Of Zinc Ion Response To Interferon-gamma Glucose Homeostasis Regulation Of Vesicle-mediated Transport Regulation Of Sequestering Of Zinc Ion Response To Interleukin-1 Zinc Ion Transmembrane Transport	Actin Cytoskeleton Reorganization
Pathways		Insulin processing Zinc efflux and compartmentalization by the SLC30 family	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Type II diabetes mellitus
GWAS		Asthma ( 21814517) Blood sugar levels ( 29403010) Body mass index ( 28892062) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting plasma glucose ( 25187374 28270201) Glycated hemoglobin levels ( 24647736 19096518 28898252) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 24002674) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lung cancer ( 27393504) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Proinsulin levels ( 21873549) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 27189021 22885922 24509480 17293876 30054458 22693455 26961502 29358691 30297969 19734900 29632382 26818947 31217584 23945395 31118516 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590 17460697 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382) Vestibular neuritis ( 30079052)	Albumin-globulin ratio ( 29403010) Aluminium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Liver enzyme levels (aspartate transaminase) ( 24124411) Machado-Joseph disease (age at onset) ( 32205469) Multiple system atrophy ( 27629089) Non-albumin protein levels ( 29403010) Non-small cell lung cancer ( 23144319) Pancreatic cancer ( 20686608) Problematic alcohol use ( 32451486) Prudent dietary pattern ( 28644415) Regular attendance at a gym or sports club ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 30224653) Tooth agenesis (third molar) ( 24172245) Urinary albumin-to-creatinine ratio ( 26631737) Weight ( 28552196)
Interacting Genes		70 interacting genes: ANK1 AQP6 ARL8B ATP13A1 BCL2L13 BSND CCL4 CD99L2 CGRRF1 CMTM7 CPLX4 CREB3L1 DERL1 ELOVL4 ERVFRD-1 FAM209A FAM210B FAXDC2 FCER1G GPR37L1 GPR42 GRM2 HMOX2 HSD17B11 JSRP1 LEUTX LMNA MUC1 NKG7 ORMDL1 OTULINL PCNA PGRMC2 PKMYT1 PLN PSCA PTPN9 REEP4 REEP6 RELL2 RMDN3 RTN3 RUSF1 SCN3B SELENOK SFT2D1 SFT2D2 SLC18A1 SLC30A3 SLC39A2 SYS1 SYT2 THAP4 THSD7B TMEM11 TMEM139 TMEM14B TMEM208 TMEM237 TMEM31 TMEM50A TMEM52B TMEM80 TMEM9 TSPAN2 VAMP1 VAMP2 YIPF4 YIPF6 ZFYVE27	25 interacting genes: AQP6 ARL13B CISD2 DARS2 FAM209A FKBP7 GJA8 GPR101 GPR152 GPR37L1 KCNJ6 KIR3DL1 LYVE1 MFSD14B MTIF3 PEX12 PIGP PLEKHO1 RANBP10 SLC14A1 SLC30A8 SPACA1 STOM SYT2 TMX2
Entrez ID		169026	80731
HPRD ID		15370	19009
Ensembl ID		ENSG00000164756	ENSG00000144229
Uniprot IDs		Q8IWU4	Q9C0I4
PDB IDs		6XPD 6XPE 6XPF
Enriched GO Terms of Interacting Partners?
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