TSPAN2 and RNF19B

Data Source:
BioGRID (two hybrid)

		TSPAN2	RNF19B
Description		tetraspanin 2	ring finger protein 19B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Plasma Membrane Integral Component Of Membrane Myelin Sheath	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Cytolytic Granule
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Inflammatory Response Brain Development Astrocyte Development Microglia Development Myelination Oligodendrocyte Differentiation Axon Development	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dysmenorrheic pain ( 27454463) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Migraine ( 27182965 23793025 27322543) Migraine without aura ( 23793025 27322543)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		35 interacting genes: ABHD16A ATP1B4 BSCL2 CD79A CLDN5 CLEC14A CREB3 CREB3L1 DCBLD2 FAM209A FKBP7 FOS GRB2 IFNGR2 KDELR3 LEPROTL1 LMNA MFF MGST3 PGRMC2 PIK3R3 RABGAP1L REEP4 RNF19B SCN3B SLC10A6 SLC30A8 SLC35C2 TMEM130 TMEM14B TMEM31 TMX2 TSPAN31 VSIR ZFYVE27	31 interacting genes: AP1M1 APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MFSD5 MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		10100	127544
HPRD ID		18233	13725
Ensembl ID		ENSG00000134198	ENSG00000116514
Uniprot IDs		B1AKP1 B2RD31 O60636	Q6ZMZ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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