PARP2 and BUB3

Data Source:
HPRD (in vivo)

		PARP2	BUB3
Description		poly(ADP-ribose) polymerase 2	BUB3 mitotic checkpoint protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Protein Binding Ubiquitin Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Body mass index ( 28892062) Left-handedness ( 32989287) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1	17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Entrez ID		10038	9184
HPRD ID		09660	04761
Ensembl ID		ENSG00000129484	ENSG00000154473
Uniprot IDs		Q9UGN5	A0A140VJF3 O43684
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
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