PARP2 and HPF1

Data Source:
BioGRID (pull down)

		PARP2	HPF1
Description		poly(ADP-ribose) polymerase 2	histone PARylation factor 1
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Protein Binding Zinc Ion Binding Histone Binding Poly-ADP-D-ribose Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death	Cellular Response To DNA Damage Stimulus Regulation Of Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)
Interacting Genes		13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1	15 interacting genes: EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2
Entrez ID		10038	54969
HPRD ID		09660	07924
Ensembl ID		ENSG00000129484	ENSG00000056050
Uniprot IDs		Q9UGN5	Q9NWY4
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N	6TX2 6TX3 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
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