PARP2 and H1-0

Data Source:
BioGRID (enzymatic study)

		PARP2	H1-0
Description		poly(ADP-ribose) polymerase 2	H1.0 linker histone
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation Nucleosome Assembly Chromatin Silencing Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)
Interacting Genes		13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1	21 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP1 PARP2 PRKCB RAD51B XBP1
Entrez ID		10038	3005
HPRD ID		09660	00819
Ensembl ID		ENSG00000129484	ENSG00000189060
Uniprot IDs		Q9UGN5	P07305
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N	6HQ1 6LA8 6LA9 6N88 6N89
Enriched GO Terms of Interacting Partners?
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