HPF1 and HMGA1

Data Source:
BioGRID (pull down)

		HPF1	HMGA1
Description		histone PARylation factor 1	high mobility group AT-hook 1
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GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Zinc Ion Binding Histone Binding Poly-ADP-D-ribose Binding	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Enzyme Binding Nuclear Receptor Coactivator Activity Structural Constituent Of Chromatin Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Regulation Of Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation	DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways			Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758 27680694) Body mass index ( 26426971 28892062 20935630) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 21998595 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 18391951 20397748 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Monocyte count ( 32888494) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		15 interacting genes: EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	64 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP UPF2
Entrez ID		54969	3159
HPRD ID		07924	02829
Ensembl ID		ENSG00000056050	ENSG00000137309
Uniprot IDs		Q9NWY4	P17096 Q5T6U8
PDB IDs		6TX2 6TX3 6X0L 6X0M 6X0N	2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?
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