HPF1 and H1-5

Data Source:
BioGRID (pull down)

		HPF1	H1-5
Description		histone PARylation factor 1	H1.5 linker histone, cluster member
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GO Annotations	Cellular Component	Nucleus	Chromatin Nucleosome Heterochromatin Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Histone Binding Poly-ADP-D-ribose Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Regulation Of Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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Diseases
GWAS
Interacting Genes		15 interacting genes: EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		54969	3009
HPRD ID		07924	00821
Ensembl ID		ENSG00000056050	ENSG00000184357
Uniprot IDs		Q9NWY4	P16401
PDB IDs		6TX2 6TX3 6X0L 6X0M 6X0N	2FE2 2RHI
Enriched GO Terms of Interacting Partners?
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