TMPRSS2 and CNIH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMPRSS2	CNIH2
Description		transmembrane serine protease 2	cornichon family AMPA receptor auxiliary protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity	Protein Binding
	Biological Process	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Localization Within Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Activity Negative Regulation Of Receptor Localization To Synapse Negative Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity
Pathways		Attachment and Entry Attachment and Entry Attachment and Entry	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs		Camostat
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)	Bipolar disorder ( 21926972 31043756) Insomnia ( 32332799) Urate levels ( 31578528)
Interacting Genes		60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1	6 interacting genes: CD53 CREB3L1 GORAB HIBADH TMEM14B TMPRSS2
Entrez ID		7113	254263
HPRD ID		03637	13078
Ensembl ID		ENSG00000184012	ENSG00000174871
Uniprot IDs		O15393	Q6PI25
PDB IDs
Enriched GO Terms of Interacting Partners?
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