CNIH2 and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CNIH2	TMPRSS2
Description		cornichon family AMPA receptor auxiliary protein 2	transmembrane serine protease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Localization Within Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Activity Negative Regulation Of Receptor Localization To Synapse Negative Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			Camostat
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Insomnia ( 32332799) Urate levels ( 31578528)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		6 interacting genes: CD53 CREB3L1 GORAB HIBADH TMEM14B TMPRSS2	60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1
Entrez ID		254263	7113
HPRD ID		13078	03637
Ensembl ID		ENSG00000174871	ENSG00000184012
Uniprot IDs		Q6PI25	O15393
PDB IDs
Enriched GO Terms of Interacting Partners?
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