TMPRSS2 and CYBC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMPRSS2	CYBC1
Description		transmembrane serine protease 2	cytochrome b-245 chaperone 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity	Protein Binding
	Biological Process	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell	Innate Immune Response Respiratory Burst After Phagocytosis
Pathways		Attachment and Entry Attachment and Entry Attachment and Entry
Drugs		Camostat
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1	64 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 BET1 C14orf180 C4orf3 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MFSD14B MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35C2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12
Entrez ID		7113	79415
HPRD ID		03637	14630
Ensembl ID		ENSG00000184012	ENSG00000178927
Uniprot IDs		O15393	A0A024R8W9 Q9BQA9
PDB IDs
Enriched GO Terms of Interacting Partners?
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