TMPRSS2 and FAXDC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMPRSS2	FAXDC2
Description		transmembrane serine protease 2	fatty acid hydroxylase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell	Positive Regulation Of Protein Phosphorylation Sterol Biosynthetic Process Positive Regulation Of Megakaryocyte Differentiation
Pathways		Attachment and Entry Attachment and Entry Attachment and Entry
Drugs		Camostat
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1	34 interacting genes: AQP6 ARL13B CD79A CGRRF1 CLDN7 CREB3L1 CYB5R3 EBP ELOVL4 ERGIC3 FCER1G FFAR2 GOLT1A GPR152 GPX8 HSD17B13 LMNA MGST3 NEMP1 PANX1 PDGFRB PGRMC2 RETREG3 SLC10A1 SLC10A6 SLC30A8 STOM STX4 TMEM106C TMEM139 TMEM31 TMEM86B TMPRSS2 TMX2
Entrez ID		7113	10826
HPRD ID		03637	12832
Ensembl ID		ENSG00000184012	ENSG00000170271
Uniprot IDs		O15393	Q96IV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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