TMPRSS2 and DEFB103B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMPRSS2	DEFB103B
Description		transmembrane serine protease 2	defensin beta 103B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Golgi Lumen
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity
	Biological Process	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell	Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Killing By Host Of Symbiont Cells Cell Chemotaxis
Pathways		Attachment and Entry Attachment and Entry Attachment and Entry	Beta defensins Defensins
Drugs		Camostat
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1	12 interacting genes: AQP6 B3GALT5 CCR6 EBP ERGIC3 ODF4 SCN3B SPATA31A7 SSMEM1 TMEM14B TMEM31 TMPRSS2
Entrez ID		7113	55894
HPRD ID		03637	05968
Ensembl ID		ENSG00000184012	ENSG00000177243
Uniprot IDs		O15393	P81534
PDB IDs			1KJ6
Enriched GO Terms of Interacting Partners?
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