PLN and HIBADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLN	HIBADH
Description		phospholamban	3-hydroxyisobutyrate dehydrogenase
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases	Branched-chain amino acid catabolism
Drugs			NADH
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794 29874175) Resting heart rate ( 27798624)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Interacting Genes		65 interacting genes: ARL13B ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BAP1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELOVL4 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MFSD5 MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35C2 SLC39A2 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2	39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		5350	11112
HPRD ID		01395	12238
Ensembl ID		ENSG00000198523	ENSG00000106049
Uniprot IDs		P26678 Q5R352	A0A024RA75 P31937
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN 6Y40	2GF2 2I9P
Enriched GO Terms of Interacting Partners?
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