HIBADH and ADAM33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HIBADH	ADAM33
Description		3-hydroxyisobutyrate dehydrogenase	ADAM metallopeptidase domain 33
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Integral Component Of Membrane
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Proteolysis
Pathways		Branched-chain amino acid catabolism
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		11112	80332
HPRD ID		12238	06173
Ensembl ID		ENSG00000106049	ENSG00000149451
Uniprot IDs		A0A024RA75 P31937	A2A2L3 Q9BZ11
PDB IDs		2GF2 2I9P	1R54 1R55
Enriched GO Terms of Interacting Partners?
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