PLN and TMEM52B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLN	TMEM52B
Description		phospholamban	transmembrane protein 52B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding	Molecular_function Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Biological_process
Pathways		Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794 29874175) Resting heart rate ( 27798624)
Interacting Genes		65 interacting genes: ARL13B ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BAP1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELOVL4 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MFSD5 MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35C2 SLC39A2 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2	68 interacting genes: ALG3 APOD APOL2 APOL3 BET1 BTN2A2 C1GALT1 C3orf52 CLDN19 CLDN4 CNIH1 CNIH3 CSGALNACT2 DNAJC30 EMD FXYD3 GAST GPR25 GPR37L1 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LTC4S MAL MARCHF2 MIP MS4A13 NINJ2 NRM NSG1 ORMDL1 PEDS1-UBE2V1 PGAP2 PLN PLP1 RTP2 SEC22A SERP1 SLC30A2 SLC30A8 SLC35A4 SLC35B4 SLC38A7 SMIM1 TF TMEM100 TMEM107 TMEM109 TMEM128 TMEM147 TMEM14C TMEM203 TMEM218 TMEM267 TMEM50B TMEM54 TMEM60 TMEM86B TMEM97 TMUB2 TRAM1L1 TRARG1 VAMP3 VAMP5 ZDHHC15
Entrez ID		5350	120939
HPRD ID		01395	08709
Ensembl ID		ENSG00000198523	ENSG00000165685
Uniprot IDs		P26678 Q5R352	Q4KMG9
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN 6Y40
Enriched GO Terms of Interacting Partners?
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