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PLN and DMPK
Number of citations of the paper that reports this interaction (PubMedID
15598648
)
11
Data Source:
HPRD
(in vivo, in vitro)
PLN
DMPK
Description
phospholamban
DM1 protein kinase
Image
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Membrane
Sarcoplasmic Reticulum
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Nuclear Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Integral Component Of Mitochondrial Outer Membrane
Nuclear Membrane
Sarcoplasmic Reticulum Membrane
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Myosin Phosphatase Regulator Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Protein Phosphorylation
Cellular Calcium Ion Homeostasis
Nuclear Envelope Organization
Regulation Of Heart Contraction
Muscle Cell Apoptotic Process
Regulation Of Myotube Differentiation
Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling
Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Regulation Of Catalytic Activity
Pathways
Ion homeostasis
Ion transport by P-type ATPases
Ion homeostasis
Drugs
Bisindolylmaleimide VIII
Diseases
GWAS
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
Hypertrophic cardiomyopathy (
33495597
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) (
30940143
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
Interacting Genes
65 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BAP1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
19 interacting genes:
ANXA7
ATN1
ATXN1
CELF1
FXYD1
GABARAP
GEMIN4
HOXA2
HSPB2
PIN1
PLN
PPP1R12A
PVR
RAC1
RAF1
RPS10
SMN1
TK1
UBQLN4
Entrez ID
5350
1760
HPRD ID
01395
05645
Ensembl ID
ENSG00000198523
ENSG00000104936
Uniprot IDs
P26678
Q5R352
B4DM55
B4DZE2
E5KR05
E5KR06
E5KR07
I6L989
Q09013
PDB IDs
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
6Y40
1WT6
2VD5
Enriched GO Terms of Interacting Partners
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