HIBADH and SCARB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HIBADH	SCARB2
Description		3-hydroxyisobutyrate dehydrogenase	scavenger receptor class B member 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity Chaperone Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Sensory Perception Of Sound Gene Expression Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Cellular Carbohydrate Catabolic Process Viral Entry Into Host Cell Regulation Of Endosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosome Organization
Pathways		Branched-chain amino acid catabolism	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 25064009 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1
Entrez ID		11112	950
HPRD ID		12238	03772
Ensembl ID		ENSG00000106049	ENSG00000138760
Uniprot IDs		A0A024RA75 P31937	A0A024RDG6 Q14108
PDB IDs		2GF2 2I9P	4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?
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