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PLN and CPLX4
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
PLN
CPLX4
Description
phospholamban
complexin 4
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Membrane
Sarcoplasmic Reticulum
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Plasma Membrane
SNARE Complex
Terminal Bouton
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
SNARE Binding
Protein Binding
Syntaxin Binding
Biological Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Visual Perception
Synaptic Vesicle Exocytosis
Regulation Of Neurotransmitter Secretion
Response To Stimulus
Pathways
Ion homeostasis
Ion transport by P-type ATPases
Drugs
Diseases
GWAS
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
Hypertrophic cardiomyopathy (
33495597
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Cardiac troponin-I levels (
31014085
)
Chronotype (
27494321
)
Macular thickness (
30535121
)
Morning vs. evening chronotype (
27494321
)
Interacting Genes
65 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BAP1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
92 interacting genes:
ADIPOQ
AGTRAP
AIG1
AOC3
APOD
AQP1
AQP9
ASGR1
ATP6V0C
BNIP2
C14orf180
C1GALT1
C3orf52
C5
CACNG1
CCL4L2
CD81
CDIPT
CDS2
CLDND2
CLEC4G
CLN6
CMTM5
CNIH1
CTSA
CTXN3
CYB5B
CYBC1
CYP4F2
DEFB127
EMD
GAD2
GIMAP1
GRM2
HACD1
HHATL
HMOX1
INSIG2
LPAR3
MAL
MALL
MAN2B2
MGAM
NINJ2
NRM
ORMDL1
PGAP2
PLN
PLP2
PLPP4
PNLIPRP1
PTPN9
RTP2
SEC22B
SELENOK
SFTPC
SLC30A2
SLC30A8
SLC35A1
SLC35A4
SLC35B4
SLC38A7
SLC39A9
SMCO4
STX3
STX8
SYNJ2BP
TF
TMEM120B
TMEM14A
TMEM14B
TMEM19
TMEM201
TMEM203
TMEM218
TMEM229B
TMEM243
TMEM254
TMEM267
TMEM60
TMEM79
TMEM86A
TMEM97
TRAF3IP3
TSPO2
UBIAD1
VAMP4
VAMP5
VKORC1
WFDC2
YIPF6
ZFPL1
Entrez ID
5350
339302
HPRD ID
01395
13091
Ensembl ID
ENSG00000198523
ENSG00000166569
Uniprot IDs
P26678
Q5R352
Q7Z7G2
PDB IDs
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
6Y40
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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