HIBADH and CNIH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HIBADH	CNIH2
Description		3-hydroxyisobutyrate dehydrogenase	cornichon family AMPA receptor auxiliary protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Protein Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Localization Within Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Activity Negative Regulation Of Receptor Localization To Synapse Negative Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity
Pathways		Branched-chain amino acid catabolism	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	Bipolar disorder ( 21926972 31043756) Insomnia ( 32332799) Urate levels ( 31578528)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	6 interacting genes: CD53 CREB3L1 GORAB HIBADH TMEM14B TMPRSS2
Entrez ID		11112	254263
HPRD ID		12238	13078
Ensembl ID		ENSG00000106049	ENSG00000174871
Uniprot IDs		A0A024RA75 P31937	Q6PI25
PDB IDs		2GF2 2I9P
Enriched GO Terms of Interacting Partners?
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