HIBADH and CDS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HIBADH	CDS2
Description		3-hydroxyisobutyrate dehydrogenase	CDP-diacylglycerol synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Phosphatidate Cytidylyltransferase Activity Protein Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Phosphatidylglycerol Biosynthetic Process CDP-diacylglycerol Biosynthetic Process Lipid Droplet Formation
Pathways		Branched-chain amino acid catabolism	Synthesis of PG
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	25 interacting genes: CPLX4 CREB3 ERGIC3 FAM209A GPR152 GPX8 HIBADH IL10RA JSRP1 LEUTX LHFPL5 LMNA MR1 MTIF3 MYG1 RNF122 SSMEM1 TIMMDC1 TMEM139 TMEM45B TMX2 TRIM55 TRIM63 TSG101 TSPAN12
Entrez ID		11112	8760
HPRD ID		12238	09150
Ensembl ID		ENSG00000106049	ENSG00000101290
Uniprot IDs		A0A024RA75 P31937	O95674
PDB IDs		2GF2 2I9P
Enriched GO Terms of Interacting Partners?
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