SRY and KPNB1

Number of citations of the paper that reports this interaction (PMID 15297880)
17

Data Source:
BioGRID (pull down)

		SRY	KPNB1
Gene Name		sex determining region Y	karyopherin (importin) beta 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Calmodulin Binding Transcription Factor Binding	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Sex Differentiation Cell Differentiation Male Sex Determination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Male Gonad Development	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus
Pathways			Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364)
Protein-Protein Interactions		7 interactors: AR EP300 HDAC3 KPNB1 SLC9A3R2 SMAD3 ZNF208	59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP
Entrez ID		6736	3837
HPRD ID		08364	04114
Ensembl ID
Uniprot IDs		A7WPU8 Q05066	B7Z752 B7ZAV6 Q14974
PDB IDs		1HRY 1HRZ 1J46 1J47 2GZK	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Negative Regulation Of Signal Transduction Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signaling Posttranscriptional Regulation Of Gene Expression Somitogenesis Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription Factor Import Into Nucleus Histone H2B Acetylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Nucleobase-containing Compound Metabolic Process Protein Stabilization Negative Regulation Of Biosynthetic Process Somite Development Positive Regulation Of Protein Import Into Nucleus Regulation Of Signal Transduction Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Segmentation Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signaling Notch Signaling Pathway Regulation Of Establishment Of Protein Localization RNA Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Evasion Or Tolerance Of Host Defenses By Virus N-terminal Peptidyl-lysine Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Import Into Nucleus Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly	Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance
Tagcloud ?		aspartic assumed bearing built called calpains certain cleavable constitute demonstrates devoid erba extremely fos gata1 gata3 glutamic initiated motifs mutagenesis myo pest proline proteases rapid reportedly specifying strengthened threonine	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Difference) ?		aspartic assumed bearing built called calpains certain cleavable constitute demonstrates devoid erba extremely fos gata1 gata3 glutamic initiated motifs mutagenesis myo pest proline proteases rapid reportedly specifying strengthened threonine	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Intersection) ?