KPNB1 and IPO8

Number of citations of the paper that reports this interaction (PMID 9214382)
144

Data Source:
HPRD (in vitro)

		KPNB1	IPO8
Gene Name		karyopherin (importin) beta 1	importin 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	Protein Binding Ran GTPase Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Intracellular Protein Transport Signal Transduction Gene Expression
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	Transcriptional regulation by small RNAs Regulatory RNA pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	4 interactors: ATXN1 KPNB1 RANGAP1 SRP19
Entrez ID		3837	10526
HPRD ID		04114	09282
Ensembl ID			ENSG00000133704
Uniprot IDs		B7Z752 B7ZAV6 Q14974	O15397
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Cytoplasmic Transport Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Ran GTPase Activity Intracellular Transport Negative Regulation Of Protein Export From Nucleus Ribosomal Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Targeting Establishment Of Localization In Cell Protein Localization To Organelle Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Intracellular Transport Of Virus Protein Import Into Nucleus, Translocation Apoptotic Nuclear Changes Regulation Of Protein Export From Nucleus
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	actb algorithms analyzing arachnoidea bestkeeper casc3 chosen deltact dura eif2b1 gapdh genorm housekeeping integration mater meningiomas mrpl19 normalization normfinder pgk1 pop4 ppia qpcr ranked reference rpl37a software validate vegfa
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	actb algorithms analyzing arachnoidea bestkeeper casc3 chosen deltact dura eif2b1 gapdh genorm housekeeping integration mater meningiomas mrpl19 normalization normfinder pgk1 pop4 ppia qpcr ranked reference rpl37a software validate vegfa
Tagcloud (Intersection) ?