KPNB1 and TAF3

Number of citations of the paper that reports this interaction (PMID 15870280)
9

Data Source:
BioGRID (pull down)

		KPNB1	TAF3
Gene Name		karyopherin (importin) beta 1	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nucleus Nucleoplasm Transcription Factor TFIID Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	P53 Binding Protein Binding Zinc Ion Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of Protein Location In Nucleus
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	4 interactors: HIST3H3 KPNA2 KPNB1 TAF10
Entrez ID		3837	83860
HPRD ID		04114	19377
Ensembl ID
Uniprot IDs		B7Z752 B7ZAV6 Q14974	Q5VWG9
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	NLS-bearing Protein Import Into Nucleus Viral Process Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus DNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport Ribosomal Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Cellular Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Protein Localization To Organelle Nitrogen Compound Metabolic Process Apoptotic DNA Fragmentation Histone Deubiquitination Cellular Response To Cytokine Stimulus Intracellular Transport Of Virus Cytoplasmic Transport Protein Import Into Nucleus, Translocation Apoptotic Nuclear Changes Response To Cytokine Histone H3 Acetylation Intracellular Protein Transport Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transcription Elongation From RNA Polymerase II Promoter Chromosome Organization Regulation Of DNA Recombination Execution Phase Of Apoptosis Telomere Maintenance DNA-templated Transcription, Elongation DNA Catabolic Process, Endonucleolytic Cellular Protein Localization Protein Deubiquitination Histone Acetylation Protein Transport Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Establishment Of Protein Localization Protein Acetylation Intracellular Transport
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	assembly box cooperatively direct directs effector enhances genotoxic global h3k4me3 include independently interactions mark modifications p53 pic preinitiation prominent promotes rapid recruitment regulate remain stimulating tata tfiid unclear yet
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	assembly box cooperatively direct directs effector enhances genotoxic global h3k4me3 include independently interactions mark modifications p53 pic preinitiation prominent promotes rapid recruitment regulate remain stimulating tata tfiid unclear yet
Tagcloud (Intersection) ?