KPNB1 and NUP98

Number of citations of the paper that reports this interaction (PMID 9144189)
59

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		KPNB1	NUP98
Gene Name		karyopherin (importin) beta 1	nucleoporin 98kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	Transporter Activity Protein Binding Structural Constituent Of Nuclear Pore Peptide Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Protein Import Into Nucleus, Docking Mitotic Cell Cycle Carbohydrate Metabolic Process DNA Replication Nucleocytoplasmic Transport Nuclear Pore Organization Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process MRNA Transport Nuclear Pore Complex Assembly Transmembrane Transport
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	18 interactors: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NFX1 NUP133 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		3837	4928
HPRD ID		04114	03012
Ensembl ID			ENSG00000110713
Uniprot IDs		B7Z752 B7ZAV6 Q14974	P52948
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW	1KO6 2Q5X 2Q5Y 3MMY
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Viral Process Mitotic Cell Cycle MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Localization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell Cycle Mitotic Cell Cycle Process Cytoplasmic Transport Nuclear Envelope Organization Glucose Transport Hexose Transport Viral Life Cycle Viral Transcription Regulation Of Glucose Transport Cell Cycle Process Nucleus Organization Intracellular Transport Carbohydrate Transport MRNA Export From Nucleus RNA Export From Nucleus Protein Transport Organelle Organization Establishment Of Protein Localization Establishment Of Localization In Cell Pathogenesis Cytokine-mediated Signaling Pathway Gene Expression Protein Import Into Nucleus Nuclear Import N-terminal Peptidyl-lysine Acetylation Nuclear Export Regulation Of Mitotic Nuclear Division RNA Biosynthetic Process Cellular Localization Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Protein Localization Mitotic Spindle Checkpoint Protein Import Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Protein Localization To Nucleus Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Intersection) ?