KPNB1 and RANBP2

Number of citations of the paper that reports this interaction (PMID 8909533)
63

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vivo, in vitro)

		KPNB1	RANBP2
Gene Name		karyopherin (importin) beta 1	RAN binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nuclear Pore Mitochondrion Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Zinc Ion Binding Ran GTPase Binding Ligase Activity
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Mitotic Cell Cycle Protein Peptidyl-prolyl Isomerization Carbohydrate Metabolic Process Protein Folding Protein Import Into Nucleus Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Protein Sumoylation Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Negative Regulation Of Glucokinase Activity Small Molecule Metabolic Process MRNA Transport Transmembrane Transport Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	Mitotic Prometaphase Separation of Sister Chromatids Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown Mitotic Anaphase SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear Pore Complex (NPC) Disassembly Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Resolution of Sister Chromatid Cohesion Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	34 interactors: AKAP13 ARID4B CALM1 CDCA8 CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MDM2 NUP62 NXF1 OPN1LW OPN1MW PARK2 RAN RANGAP1 SAE1 SENP1 SP100 SUMO1 TAF1 TNPO1 TOP2B TP53 UBA2 UBE2I UBTD1 XPO1 XPOT
Entrez ID		3837	5903
HPRD ID		04114	03111
Ensembl ID			ENSG00000153201
Uniprot IDs		B7Z752 B7ZAV6 Q14974	P49792
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Viral Process Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Localization To Organelle Cytoplasmic Transport Peptidyl-lysine Modification Protein Import Into Nucleus Nuclear Import Cellular Localization Protein Sumoylation Protein Import NLS-bearing Protein Import Into Nucleus Positive Regulation Of Metabolic Process Cellular Protein Localization Establishment Of Localization In Cell Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Protein Localization Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization To Organelle Nuclear Export Cellular Response To Organic Substance Regulation Of Protein Localization Regulation Of Protein Catabolic Process Cell Cycle Regulation Of Intracellular Protein Transport Protein Targeting Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Establishment Of Protein Localization SMT3-dependent Protein Catabolic Process Intracellular Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?