KPNB1 and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 12062430)
3

Data Source:
HPRD (in vitro)

		KPNB1	CSNK1A1
Gene Name		karyopherin (importin) beta 1	casein kinase 1, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)	Esophageal cancer ( 21642993)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		3837	1452
HPRD ID		04114	02739
Ensembl ID			ENSG00000113712
Uniprot IDs		B7Z752 B7ZAV6 Q14974	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?