KPNB1 and PRKD3

Number of citations of the paper that reports this interaction (PMID 16380377)
7

Data Source:
HPRD (in vivo)

		KPNB1	PRKD3
Gene Name		karyopherin (importin) beta 1	protein kinase D3
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nucleoplasm Cytoplasm Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	9 interactors: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 NUDT3 SKA2 VAMP2
Entrez ID		3837	23683
HPRD ID		04114	06151
Ensembl ID			ENSG00000115825
Uniprot IDs		B7Z752 B7ZAV6 Q14974	O94806
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW	2D9Z
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Protein Import Into Nucleus Nuclear Import Protein Import NLS-bearing Protein Import Into Nucleus Protein Localization To Nucleus Protein Import Into Nucleus, Translocation Cytoplasmic Transport Nucleocytoplasmic Transport Nuclear Transport Energy Derivation By Oxidation Of Organic Compounds Intracellular Protein Transport Establishment Of Protein Localization To Organelle Regulation Of DNA Recombination Negative Regulation Of UDP-glucose Catabolic Process Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Establishment Of Localization In Cell Negative Regulation Of Intracellular Signal Transduction Generation Of Precursor Metabolites And Energy Protein Targeting Protein Localization To Organelle Negative Regulation Of Type B Pancreatic Cell Development Immune Response Viral Process Cellular Localization Signaling Cellular Protein Localization Cell Communication Cellular Response To Cytokine Stimulus Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Eosinophil Degranulation Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Isotype Switching To IgE Isotypes Energy Reserve Metabolic Process Protein Transport Establishment Of Protein Localization Hypermethylation Of CpG Island Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Cell Growth Intracellular Transport Positive Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Interleukin-3 Response To Cytokine Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Establishment Of Vesicle Localization
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Intersection) ?