ITIH5 and RB1CC1

Data Source:
BioGRID (two hybrid)

		ITIH5	RB1CC1
Description		inter-alpha-trypsin inhibitor heavy chain 5	RB1 inducible coiled-coil 1
Image		No pdb structure
GO Annotations	Cellular Component	Collagen-containing Extracellular Matrix	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Macroautophagy Regulation Of Macroautophagy Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Metabolite levels ( 23823483) Planum temporale asymmetry index ( 31887566)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		10 interacting genes: BAG4 BRCA1 CHEK2 ESR2 HMMR NOTCH2 PPM1D RAD51 RB1CC1 XRCC3	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		80760	9821
HPRD ID		13747	06019
Ensembl ID		ENSG00000123243	ENSG00000023287
Uniprot IDs		A0A096LP62 C9J2H1 G5E9D8 Q86UX2 Q96JW9	Q8TDY2
PDB IDs			6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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