ITIH5 and PPM1D

Data Source:
BioGRID (two hybrid)

		ITIH5	PPM1D
Description		inter-alpha-trypsin inhibitor heavy chain 5	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways			Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Metabolite levels ( 23823483) Planum temporale asymmetry index ( 31887566)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		10 interacting genes: BAG4 BRCA1 CHEK2 ESR2 HMMR NOTCH2 PPM1D RAD51 RB1CC1 XRCC3	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		80760	8493
HPRD ID		13747	05482
Ensembl ID		ENSG00000123243	ENSG00000170836
Uniprot IDs		A0A096LP62 C9J2H1 G5E9D8 Q86UX2 Q96JW9	A0A0S2Z4M2 O15297
PDB IDs
Enriched GO Terms of Interacting Partners?
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