CBX2 and DHX57

Data Source:
BioGRID (two hybrid)

		CBX2	DHX57
Description		chromobox 2	DExH-box helicase 57
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Intracellular Anatomical Structure
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Brain morphology (MOSTest) ( 32665545)	Obesity-related traits ( 23251661)
Interacting Genes		25 interacting genes: BOLL CYSRT1 DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 PCGF2 PHC2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RNF2 RYBP TRIM55 TRIM63	22 interacting genes: CARD10 CBX2 CEP44 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP9-4 NAA10 PLAGL2 RBMY1A1 RSPO4 ZNF473 ZNF587 ZNF837
Entrez ID		84733	90957
HPRD ID		14397	09919
Ensembl ID		ENSG00000173894	ENSG00000163214
Uniprot IDs		Q14781	Q6P158
PDB IDs		2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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