UCHL1 and LAMP2

Data Source:
HPRD (in vivo)

		UCHL1	LAMP2
Description		ubiquitin C-terminal hydrolase L1	lysosomal associated membrane protein 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Membrane Raft Extracellular Exosome Integral Component Of Autophagosome Membrane Membrane Microdomain Ficolin-1-rich Granule Membrane Lysosomal Matrix
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity	Platelet Degranulation Protein Targeting Cellular Response To Starvation Protein Import Regulation Of Protein Stability Neutrophil Degranulation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Establishment Of Protein Localization To Organelle Autophagosome Maturation Lysosomal Protein Catabolic Process
Pathways		UCH proteinases	Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)	Danon disease; X-linked vacuolar cardiomyopathy and myopathy
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	5 interacting genes: AP4M1 APLNR CTSA PIAS4 UCHL1
Entrez ID		7345	3920
HPRD ID		01877	02396
Ensembl ID		ENSG00000154277	ENSG00000005893
Uniprot IDs		P09936 V9HW74	P13473
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ	2MOF 2MOM
Enriched GO Terms of Interacting Partners?
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