Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
UCHL1 and TINF2
Data Source:
BioGRID
(two hybrid)
UCHL1
TINF2
Description
ubiquitin C-terminal hydrolase L1
TERF1 interacting nuclear factor 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Perinucleolar Chromocenter
Nuclear Matrix
Nuclear Body
Shelterin Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Omega Peptidase Activity
Ligase Activity
Ubiquitin Protein Ligase Binding
Alpha-2A Adrenergic Receptor Binding
Ubiquitin Binding
DNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Regulation Of Macroautophagy
Protein Deubiquitination
Protein Phosphopantetheinylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Protein ADP-ribosylation
Telomere Capping
Telomere Assembly
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways
UCH proteinases
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Phenethyl Isothiocyanate
Diseases
Parkinson's disease (PD)
Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS
Cognitive performance (
19734545
)
Metabolite levels (
23823483
)
Leukocyte telomere length (
31171785
)
Platelet count (
29403010
)
Interacting Genes
28 interacting genes:
ADRA2A
ADRA2B
ADRA2C
ADRB2
AKT1
CBX1
CDKN1B
COPS5
EGFR
HSP90AA1
HSPA8
LAMP2
NCAM1
NEDD8
PLA2G2A
PRKN
RANBP9
SMN1
TERF2IP
TINF2
TNFRSF1A
TRIM54
TRIM63
UBC
UBE2I
USP15
USP21
USP28
89 interacting genes:
ACD
ACOT7
ACTB
ADA
AFAP1L2
AIPL1
AK1
ANKMY2
ANXA4
ANXA5
ANXA8L1
APOBEC3F
APPL2
ARHGDIA
ARID3B
BAG3
BIN2
CALD1
CCDC43
CCDC9
CKB
CLK3
CPNE3
CRYGS
CTTN
DBN1
DCX
DHFR2
DPP3
EEF1D
EIF4B
ENO2
FAM131B
FERMT3
FKBP6
GAPDH
GNMT
HNMT
HOXA3
HSP90AB1
IPO5
KCTD17
LASP1
LDHA
LGALSL
LTA4H
MAP2K3
MTNR1B
NCDN
NOL3
NUDC
NUDCD2
OR2H1
PAGE2
PAK1IP1
PEX5
PFKP
PGM1
PGM2
PHPT1
PKM
PPP1R2
PPP6R3
PRKCB
REM2
RGS14
RPSA
SARS1
SCRN2
SIAH2
STUB1
SULT1C2
TAGLN
TBL1X
TERF1
TERF2
TOMM34
TPP1
TRIM15
TRIM16
TRIP10
TUBB
TUBB4B
TXNDC17
UCHL1
VIPR1
YWHAG
ZFP36L1
ZNF790
Entrez ID
7345
26277
HPRD ID
01877
16056
Ensembl ID
ENSG00000154277
ENSG00000092330
Uniprot IDs
P09936
V9HW74
Q9BSI4
PDB IDs
2ETL
2LEN
3IFW
3IRT
3KVF
3KW5
4DM9
4JKJ
3BQO
3BU8
5XYF
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?