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UCHL1 and USP21
Data Source:
BioGRID
(enzymatic study)
UCHL1
USP21
Description
ubiquitin C-terminal hydrolase L1
ubiquitin specific peptidase 21
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Omega Peptidase Activity
Ligase Activity
Ubiquitin Protein Ligase Binding
Alpha-2A Adrenergic Receptor Binding
Ubiquitin Binding
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Biological Process
Regulation Of Macroautophagy
Protein Deubiquitination
Protein Phosphopantetheinylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAP Kinase Activity
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Pathways
UCH proteinases
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Drugs
Phenethyl Isothiocyanate
Diseases
Parkinson's disease (PD)
GWAS
Cognitive performance (
19734545
)
Metabolite levels (
23823483
)
Interacting Genes
28 interacting genes:
ADRA2A
ADRA2B
ADRA2C
ADRB2
AKT1
CBX1
CDKN1B
COPS5
EGFR
HSP90AA1
HSPA8
LAMP2
NCAM1
NEDD8
PLA2G2A
PRKN
RANBP9
SMN1
TERF2IP
TINF2
TNFRSF1A
TRIM54
TRIM63
UBC
UBE2I
USP15
USP21
USP28
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
Entrez ID
7345
27005
HPRD ID
01877
05291
Ensembl ID
ENSG00000154277
ENSG00000143258
Uniprot IDs
P09936
V9HW74
Q9UK80
PDB IDs
2ETL
2LEN
3IFW
3IRT
3KVF
3KW5
4DM9
4JKJ
2Y5B
3I3T
3MTN
Enriched GO Terms of Interacting Partners
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