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UCHL1 and HSPA8
Data Source:
HPRD
(in vivo)
UCHL1
HSPA8
Description
ubiquitin C-terminal hydrolase L1
heat shock protein family A (Hsp70) member 8
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Late Endosome
Autophagosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Dendrite
Secretory Granule Lumen
Melanosome
Terminal Bouton
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Photoreceptor Ribbon Synapse
Glycinergic Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Postsynaptic Specialization Membrane
Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Omega Peptidase Activity
Ligase Activity
Ubiquitin Protein Ligase Binding
Alpha-2A Adrenergic Receptor Binding
Ubiquitin Binding
G Protein-coupled Receptor Binding
Phosphatidylserine Binding
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Clathrin-uncoating ATPase Activity
Biological Process
Regulation Of Macroautophagy
Protein Deubiquitination
Protein Phosphopantetheinylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAP Kinase Activity
MRNA Splicing, Via Spliceosome
Protein Folding
Response To Unfolded Protein
Neurotransmitter Secretion
Cellular Response To Starvation
Viral Process
Vesicle-mediated Transport
Cytokine-mediated Signaling Pathway
Regulation Of Protein Stability
Cellular Response To Unfolded Protein
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Neutrophil Degranulation
Regulation Of MRNA Stability
Positive Regulation By Host Of Viral Genome Replication
Negative Regulation Of Transcription, DNA-templated
ATP Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Chaperone Cofactor-dependent Protein Refolding
Regulation Of Cell Cycle
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Late Endosomal Microautophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy
Clathrin Coat Disassembly
Regulation Of Postsynapse Organization
Regulation Of Cellular Response To Heat
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Slow Axonal Transport
Pathways
UCH proteinases
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Drugs
Phenethyl Isothiocyanate
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Diseases
Parkinson's disease (PD)
GWAS
Cognitive performance (
19734545
)
Metabolite levels (
23823483
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Interacting Genes
28 interacting genes:
ADRA2A
ADRA2B
ADRA2C
ADRB2
AKT1
CBX1
CDKN1B
COPS5
EGFR
HSP90AA1
HSPA8
LAMP2
NCAM1
NEDD8
PLA2G2A
PRKN
RANBP9
SMN1
TERF2IP
TINF2
TNFRSF1A
TRIM54
TRIM63
UBC
UBE2I
USP15
USP21
USP28
91 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CAPZA1
CAPZB
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DNAJB1
DPP3
DYNLL1
EGFR
ENO1
ERBB3
ERH
ESR1
FANCC
FBP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
METTL21A
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
SGTA
SIRPA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCAP
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
VHL
YWHAG
YWHAQ
Entrez ID
7345
3312
HPRD ID
01877
07205
Ensembl ID
ENSG00000154277
ENSG00000109971
Uniprot IDs
P09936
V9HW74
P11142
Q53HF2
V9HW22
PDB IDs
2ETL
2LEN
3IFW
3IRT
3KVF
3KW5
4DM9
4JKJ
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
Enriched GO Terms of Interacting Partners
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