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UCHL1 and PLA2G2A
Data Source:
BioGRID
(enzymatic study)
UCHL1
PLA2G2A
Description
ubiquitin C-terminal hydrolase L1
phospholipase A2 group IIA
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Extracellular Region
Extracellular Space
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Secretory Granule
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Omega Peptidase Activity
Ligase Activity
Ubiquitin Protein Ligase Binding
Alpha-2A Adrenergic Receptor Binding
Ubiquitin Binding
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Regulation Of Macroautophagy
Protein Deubiquitination
Protein Phosphopantetheinylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAP Kinase Activity
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Inflammatory Response
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Antimicrobial Humoral Response
Cytolysis
Low-density Lipoprotein Particle Remodeling
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Intestinal Stem Cell Homeostasis
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Neutrophil Activation
Pathways
UCH proteinases
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides
Drugs
Phenethyl Isothiocyanate
Indomethacin
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
Lauric acid
(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid
Elaidamide
(2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate
KH064
Suramin
Varespladib methyl
Diseases
Parkinson's disease (PD)
GWAS
Cognitive performance (
19734545
)
Metabolite levels (
23823483
)
Blood protein levels (
30072576
29875488
)
group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP (
31070471
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Interacting Genes
28 interacting genes:
ADRA2A
ADRA2B
ADRA2C
ADRB2
AKT1
CBX1
CDKN1B
COPS5
EGFR
HSP90AA1
HSPA8
LAMP2
NCAM1
NEDD8
PLA2G2A
PRKN
RANBP9
SMN1
TERF2IP
TINF2
TNFRSF1A
TRIM54
TRIM63
UBC
UBE2I
USP15
USP21
USP28
26 interacting genes:
ALOX12
BAG6
CEP70
CRMP1
DCN
ITGAV
ITGB3
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
Entrez ID
7345
5320
HPRD ID
01877
01397
Ensembl ID
ENSG00000154277
ENSG00000188257
Uniprot IDs
P09936
V9HW74
A0A024RA96
P14555
PDB IDs
2ETL
2LEN
3IFW
3IRT
3KVF
3KW5
4DM9
4JKJ
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
5G3N
Enriched GO Terms of Interacting Partners
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