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TNNT1 and NFE2L2
Data Source:
BioGRID
(two hybrid)
TNNT1
NFE2L2
Description
troponin T1, slow skeletal type
nuclear factor, erythroid 2 like 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Troponin Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Molecular Function
Protein Binding
Tropomyosin Binding
Troponin T Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Biological Process
Skeletal Muscle Contraction
Muscle Contraction
Transition Between Fast And Slow Fiber
Muscle Filament Sliding
Slow-twitch Skeletal Muscle Fiber Contraction
Sarcomere Organization
Negative Regulation Of Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Viral Process
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Cellular Response To Drug
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Striated Muscle Contraction
Drugs
Diseases
Nemaline myopathy
GWAS
Height (
31562340
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
69 interacting genes:
ARMC8
BLOC1S2
BMPR1B
CCDC136
CCDC85B
CHD3
CLIP4
DDX5
EEF1G
FAF1
FXR2
FYN
HAP1
HMGXB4
HSP90AB1
IMMT
KAT5
KRT27
KRT40
LARP1
LDOC1
MARS1
MORF4L1
MYOM2
NACAD
NAGK
NFE2L2
NINL
NSG2
OSBP2
OSM
PI4KA
PLEKHF1
PNMA1
PPFIA1
PRKG1
PSMC5
SBK3
SDCBP2
SEC31A
SERPINA4
SH3GL3
SMAD1
SMAD2
SMURF1
SNW1
TBPL1
TFIP11
TGFBR1
TMEM98
TNNC1
TNNI1
TNNI2
TNNI3
TNNT2
TPM1
TPM3
TRA2A
TRIM63
TSPYL2
TULP3
UBE2D1
VIM
WDCP
ZC3H15
ZKSCAN5
ZMYND19
ZNF250
ZNF768
37 interacting genes:
ATF4
BPTF
CASP1
CASP3
CDH1
CHD6
COPS7A
CREB3
CREBBP
DCAF11
EIF2AK3
GSK3B
JUN
JUND
KDM1A
KEAP1
KPNA3
MAFF
MAFG
MAFK
MAPK7
MAPK8
NCOR2
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
SUMO1
SUMO2
TNNT1
TRIM24
UBE2E2
WAC
Entrez ID
7138
4780
HPRD ID
01841
02732
Ensembl ID
ENSG00000105048
ENSG00000116044
Uniprot IDs
P13805
Q16236
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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