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TNNT1 and SMAD1
Data Source:
HPRD
(in vivo)
TNNT1
SMAD1
Description
troponin T1, slow skeletal type
SMAD family member 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Troponin Complex
Chromatin
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein-containing Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
Protein Binding
Tropomyosin Binding
Troponin T Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Biological Process
Skeletal Muscle Contraction
Muscle Contraction
Transition Between Fast And Slow Fiber
Muscle Filament Sliding
Slow-twitch Skeletal Muscle Fiber Contraction
Sarcomere Organization
Negative Regulation Of Muscle Contraction
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Protein Deubiquitination
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Pathways
Striated Muscle Contraction
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Drugs
Diseases
Nemaline myopathy
GWAS
Height (
31562340
)
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Interacting Genes
69 interacting genes:
ARMC8
BLOC1S2
BMPR1B
CCDC136
CCDC85B
CHD3
CLIP4
DDX5
EEF1G
FAF1
FXR2
FYN
HAP1
HMGXB4
HSP90AB1
IMMT
KAT5
KRT27
KRT40
LARP1
LDOC1
MARS1
MORF4L1
MYOM2
NACAD
NAGK
NFE2L2
NINL
NSG2
OSBP2
OSM
PI4KA
PLEKHF1
PNMA1
PPFIA1
PRKG1
PSMC5
SBK3
SDCBP2
SEC31A
SERPINA4
SH3GL3
SMAD1
SMAD2
SMURF1
SNW1
TBPL1
TFIP11
TGFBR1
TMEM98
TNNC1
TNNI1
TNNI2
TNNI3
TNNT2
TPM1
TPM3
TRA2A
TRIM63
TSPYL2
TULP3
UBE2D1
VIM
WDCP
ZC3H15
ZKSCAN5
ZMYND19
ZNF250
ZNF768
160 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
Entrez ID
7138
4086
HPRD ID
01841
03356
Ensembl ID
ENSG00000105048
ENSG00000170365
Uniprot IDs
P13805
Q15797
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
Enriched GO Terms of Interacting Partners
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