BARD1 and UBE2K

Data Source:
BioGRID (pull down)

		BARD1	UBE2K
Description		BRCA1 associated RING domain 1	ubiquitin conjugating enzyme E2 K
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex	Nucleus Cytosol Filopodium Tip
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Double-strand Break Processing Tissue Homeostasis DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Protein Deubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		125 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AX H2BC21 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655	95 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		580	3093
HPRD ID		03354	04165
Ensembl ID		ENSG00000138376	ENSG00000078140
Uniprot IDs		A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728	B3KSH4 B4DIZ2 P61086
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2	1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7
Enriched GO Terms of Interacting Partners?
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