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BARD1 and FAM9B
Data Source:
BioGRID
(two hybrid)
BARD1
FAM9B
Description
BRCA1 associated RING domain 1
family with sequence similarity 9 member B
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Synaptonemal Complex
Nucleoplasm
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Protein Binding
Biological Process
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Spermatid Development
Meiotic Cell Cycle
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Age at voice drop (
27182965
)
Androgen levels (
22936694
)
Creatinine levels (
29403010
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
28869591
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Male-pattern baldness (
29146897
27182965
)
Metabolite levels (
23823483
)
Interacting Genes
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
142 interacting genes:
ABT1
ACP6
ANKRD36B
AP1M1
ASB6
ATF7
AURKAIP1
BAG6
BAIAP2L2
BARD1
BCL2A1
BET1
BLOC1S2
BRME1
BYSL
C16orf72
C8orf33
CADPS
CCDC106
CCDC116
CCDC198
CCDC70
CDC23
CDC37
CDC42EP4
CDCA7L
CDSN
CENPL
CEP57L1
CEP95
CHRAC1
CLCN1
CMTM6
COL20A1
CSDE1
CWF19L2
DAPK2
DAXX
DENND2D
DGUOK
DNAJC15
DNAJC4
EBNA1BP2
ECH1
EIF3G
ELOA
FAM161A
FAM9A
FASTKD3
FCHSD2
FERD3L
FNDC11
GFOD1
GOPC
GPX1
GRAMD4
GSTK1
HNRNPLL
IBSP
ISCU
JAZF1
LBX1
LIN7A
LINC02363
LMNA
LNX1
LYRM2
MAB21L3
MFAP1
MOB1A
MORF4L1
MORF4L2
MRPL10
MRPL28
MRPL9
MRRF
MYG1
MYO15B
NDE1
NDUFB10
NEBL
NOL4
NOTO
PAGE1
PAGE3
PHYH
PIN4
POLL
PPARA
PPP1R18
PRPF3
PSMD14
PTRH1
RAB17
RAD51B
RBM17
RBM23
RMND1
RNF8
RPL9
RSL24D1
RUBCN
RUSC1
SDCBP
SDCBP2
SERPINE2
SFN
SLC16A3
SLPI
SMARCB1
SMN1
SMN2
SNAP29
SNAP47
SNX20
SRRM4
STK3
SUCLA2
SURF6
SYT17
TBC1D25
TBRG4
TCEA2
TCEANC
TGFBI
TOM1L2
TRMT61B
TSG101
TUFM
TXN2
UBE2E2
URB1-AS1
WT1
XRCC4
YARS2
ZCCHC10
ZGPAT
ZNF41
ZNF410
ZNF567
ZNF614
ZNF777
Entrez ID
580
171483
HPRD ID
03354
15955
Ensembl ID
ENSG00000138376
ENSG00000177138
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
A0A024RBV3
Q8IZU0
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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