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BARD1 and HAP1
Data Source:
BioGRID
(pull down, two hybrid)
HPRD
(two hybrid, in vitro)
BARD1
HAP1
Description
BRCA1 associated RING domain 1
huntingtin associated protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Nucleolus
Mitochondrion
Lysosome
Early Endosome
Autophagosome
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Cytoskeleton
Synaptic Vesicle
Actin Cytoskeleton
Inclusion Body
Dendrite
Growth Cone
Cytoplasmic Vesicle
Dendritic Spine
Axon Cytoplasm
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Signaling Receptor Binding
Protein Binding
Myosin Binding
Ion Channel Binding
Brain-derived Neurotrophic Factor Binding
Biological Process
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Protein Targeting
Exocytosis
Autophagy
Chemical Synaptic Transmission
Brain Development
Anterograde Axonal Transport
Retrograde Axonal Transport
Protein Localization
Regulation Of Exocytosis
Cerebellum Development
Hypothalamus Cell Differentiation
Neurogenesis
Cell Projection Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Positive Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Neurotrophin TRK Receptor Signaling Pathway
Mitochondrion Distribution
Positive Regulation Of Neurogenesis
Anterograde Axonal Transport Of Mitochondrion
Negative Regulation Of Amyloid-beta Formation
Regulation Of Organelle Transport Along Microtubule
Positive Regulation Of Non-motile Cilium Assembly
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Developmental language disorder (syntactic complexity) (
27016271
)
Esophageal cancer (squamous cell) (
22960999
)
Interacting Genes
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
93 interacting genes:
AEN
ANTKMT
APLP1
ATP5MF
BARD1
BRD7
C1orf216
C2CD6
C7orf25
C8orf33
CBX8
CCDC113
CCDC13
CDC73
CDK18
CDK5RAP2
COL9A2
CRIP1
DCTN1
DDX49
DEFB1
EIF3E
FAM50B
FEZ1
GABARAPL2
GADD45G
GIT1
GPRASP2
HDAC4
HGS
HMOX2
HOXB5
HSPA1A
HSPA4
HTT
IMMT
ING5
KAT5
KAT7
KATNBL1
KBTBD7
KPNA2
LRIF1
LUC7L2
MPP3
MRPS9
MSGN1
NAP1L5
NDUFB9
NEUROD1
NIPSNAP3A
NOD2
NOP53
PABPC4
PCM1
PDCD7
PFDN1
PKN1
PPID
PPOX
PPP1R18
PRPF31
PSMD11
RER1
RHPN1
RIF1
RPS10
RPS25
SCNM1
SNAPIN
SRSF4
STX5
TAF1D
TBP
TIMM17A
TNNT1
TNNT3
TOMM20
TSPYL1
UTP3
VIM
ZFP1
ZMAT2
ZNF124
ZNF20
ZNF24
ZNF33B
ZNF490
ZNF572
ZNF575
ZNF648
ZNF691
ZNF835
Entrez ID
580
9001
HPRD ID
03354
02972
Ensembl ID
ENSG00000138376
ENSG00000173805
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
P54257
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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