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BARD1 and HSF2BP
Data Source:
BioGRID
(two hybrid)
BARD1
HSF2BP
Description
BRCA1 associated RING domain 1
heat shock transcription factor 2 binding protein
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Chromosome
Cytosol
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Protein Binding
Biological Process
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Transcription By RNA Polymerase II
Male Meiosis I
Spermatogenesis
Double-strand Break Repair Involved In Meiotic Recombination
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Eosinophilic esophagitis (
25017104
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Plasma anti-thyroid peroxidase levels (
29678681
)
Pursuit maintenance gain (
29064472
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
Interacting Genes
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
293 interacting genes:
ABI2
ABLIM1
ACTN3
ADD1
ANAPC16
ANKRD55
ANKS1B
ARHGAP45
ARHGEF3
ARHGEF4
ARHGEF5
ARHGEF6
ATXN7L2
BARD1
BAX
BAZ2B
BCAS2
BEND7
BEX2
BLK
BMI1
BYSL
C10orf88
C18orf54
C1orf35
C1orf94
C2CD6
C4orf46
C5orf49
C7orf31
C9orf24
CAMSAP3
CARD9
CASS4
CBX8
CBY2
CCDC113
CCDC116
CCDC120
CCDC13
CCDC130
CCDC146
CCDC185
CCDC187
CCDC198
CCDC33
CCHCR1
CCSER1
CDC37
CDC73
CDCA7L
CDR2L
CDYL2
CEP55
CEP57
CKS1B
CLIP4
CNNM1
CNNM3
CNOT2
COIL
CTSZ
CTTNBP2
CTTNBP2NL
CWF19L2
DALRD3
DCDC2B
DEFB112
DMAP1
DMRT3
DOCK8
DPF2
DUSP13
EAF1
EIF3D
ELOA2
EMD
ENKD1
EPHB3
EPM2AIP1
FAM107A
FAM110A
FAM110B
FAM124B
FAM161B
FAM214B
FAM228A
FAM90A1
FBXO44
FHL2
FHL3
FLYWCH1
FUT9
GAS2L2
GAS8
GCM2
GEM
GGN
GNL3L
GOLGA1
GPANK1
GPATCH2L
GPBP1
GPKOW
GPSM3
H2AW
HASPIN
HCK
HDAC4
HEXIM2
HEY2
HNRNPH2
HOMEZ
HOXB5
HOXC8
HSF2
IER2
IL16
INO80B
INPP5J
INSYN2A
IPMK
IQCC
ITGB3BP
JRK
KANK2
KAT5
KIAA0408
KIF24
KIF5B
KIF9
KIFC3
KLF4
L3MBTL2
L3MBTL3
L3MBTL4
LAGE3
LEP
LGALS4
LMO4
LNX1
LRRC29
LRRC56
LRRN4
LUZP4
MAGED1
MAGOHB
MARCHF7
MEF2A
MFAP1
MISP
MKRN3
MVB12A
MYOZ3
NAB2
NCK2
NFIL3
NHSL2
NME4
NPPA
NSMF
NTAQ1
NUDT10
NXF1
ODF3B
ODF3L2
OPTN
P2RX7
PAK6
PAPSS2
PARD6B
PDLIM7
PICK1
PKD2
PKN1
PKP1
PLB1
PLEKHA2
PLEKHA7
PNMA5
POGZ
POLDIP3
POMC
PPM1K
PPP1R18
PPP1R32
PRPF18
PRPF3
PRPF31
PRR5L
PSMA1
PSTPIP1
RAB11FIP2
RAB36
RAB3IL1
RAD51D
RALY
RBM17
RBM41
RBM48
RCOR3
REXO4
RIBC1
RIN1
RNF135
RNF169
ROBO3
RPS28
RTP5
SAMD4A
SAPCD1
SART1
SAXO1
SCNM1
SDCBP
SELENOV
SEMA3B
SEMA4C
SEPTIN1
SEPTIN9
SETDB1
SH2D4A
SHFL
SHISA6
SIRPA
SLAIN1
SLC6A1
SMARCB1
SMARCD1
SMG9
SNAPC1
SNW1
SNX18
SNX21
SPATA22
SPEG
SPG7
SPRED1
SPRY1
SYCE1L
SYNGAP1
TAB2
TAGAP
TASOR2
TBC1D1
TBC1D30
TCEA2
TCF19
TEPSIN
TFIP11
THAP6
TMEFF2
TMSB4X
TNS4
TOX2
TP53BP2
TRAF5
TRARG1
TSEN15
TSGA10IP
TSHZ3
TTC23
TTC9C
TULP3
UBE2I
UPF2
UPRT
USP20
VEZF1
VHL
VPS72
WASF1
WASHC1
WDR25
ZBTB16
ZBTB42
ZC2HC1C
ZCWPW2
ZFC3H1
ZGPAT
ZNF185
ZNF250
ZNF417
ZNF511
ZNF564
ZNF581
ZNF587
ZNF648
ZNF688
ZNF774
ZNF835
ZNF84
ZNF844
Entrez ID
580
11077
HPRD ID
03354
05186
Ensembl ID
ENSG00000138376
ENSG00000160207
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
O75031
Q6IAT7
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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