BARD1 and BCCIP

Data Source:
BioGRID (two hybrid)

		BARD1	BCCIP
Description		BRCA1 associated RING domain 1	BRCA2 and CDKN1A interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex	Nucleus Nucleoplasm Centrosome Centriole Cytosol Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Spindle Pole
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Kinase Regulator Activity
	Biological Process	DNA Double-strand Break Processing Tissue Homeostasis DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Protein Deubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization DNA Repair Mitotic Spindle Organization Microtubule Anchoring Neuroendocrine Cell Differentiation Mitotic Spindle Assembly
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		125 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AX H2BC21 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655	26 interacting genes: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDC42 CDKN1A CENPJ CSNK2B FCF1 H2BC15 ITSN2 MRPS9 PDGFB PTN PTPRM RAD51 RALY RPL23 RPL38 SRC TENT5A TP53 YY1 ZNF138 ZNF19
Entrez ID		580	56647
HPRD ID		03354	16542
Ensembl ID		ENSG00000138376	ENSG00000107949
Uniprot IDs		A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728	Q9P287
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2
Enriched GO Terms of Interacting Partners?
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