UBE2K and TRAF7

Data Source:
BioGRID (two hybrid)

		UBE2K	TRAF7
Description		ubiquitin conjugating enzyme E2 K	TNF receptor associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Filopodium Tip	Ubiquitin Ligase Complex Nucleolus Plasma Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Ribosomal Large Subunit Assembly Activation Of MAPKKK Activity Apoptotic Process Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Diastolic blood pressure ( 30578418) Height ( 28552196) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		95 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	12 interacting genes: CDC42 CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6
Entrez ID		3093	84231
HPRD ID		04165	06977
Ensembl ID		ENSG00000078140	ENSG00000131653
Uniprot IDs		B3KSH4 B4DIZ2 P61086	B3KQY7 Q6Q0C0
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7
Enriched GO Terms of Interacting Partners?
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