UBE2K and DDX58

Data Source:
BioGRID (enzymatic study)

		UBE2K	DDX58
Description		ubiquitin conjugating enzyme E2 K	DExD/H-box helicase 58
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GO Annotations	Cellular Component	Nucleus Cytosol Filopodium Tip	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Ruffle Membrane Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Viral Process Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Blood protein levels ( 30072576) Bone mineral density (spine) and age at menarche ( 26312577) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory skin disease ( 25574825) Metabolite levels ( 23823483) Psoriasis ( 25903422 25574825 23143594) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252)
Interacting Genes		95 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	16 interacting genes: CYLD MAVS PRKCG RNF122 RNF135 SNX5 THAP12 TRIM25 TRIM40 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP15 USP3
Entrez ID		3093	23586
HPRD ID		04165	13131
Ensembl ID		ENSG00000078140	ENSG00000107201
Uniprot IDs		B3KSH4 B4DIZ2 P61086	O95786
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7	2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV
Enriched GO Terms of Interacting Partners?
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