USP28 and UCHL1

Data Source:
BioGRID (enzymatic study)

		USP28	UCHL1
Description		ubiquitin specific peptidase 28	ubiquitin C-terminal hydrolase L1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Regulation Of Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity
Pathways		Ub-specific processing proteases	UCH proteinases
Drugs			Phenethyl Isothiocyanate
Diseases			Parkinson's disease (PD)
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		57646	7345
HPRD ID		15632	01877
Ensembl ID		ENSG00000048028	ENSG00000154277
Uniprot IDs		B4E3L3 Q96RU2	P09936 V9HW74
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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