USP28 and CLSPN

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		USP28	CLSPN
Description		ubiquitin specific peptidase 28	claspin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint
Pathways		Ub-specific processing proteases	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	11 interacting genes: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7
Entrez ID		57646	63967
HPRD ID		15632	09257
Ensembl ID		ENSG00000048028	ENSG00000092853
Uniprot IDs		B4E3L3 Q96RU2	Q9HAW4
PDB IDs		2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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